Targeting BRF2 in Cancer Using Repurposed Drugs

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis rates in cells. This pathway is overactivated in brains of patients with Alzheimer’s disease and related disorders and has recently emerged as a promising therape...

Chromatin targeting drugs in cancer and immunity.

Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized cell functions. Knowledge about post-synthetic DNA and histone modifications as well as information about the rules that guide the formation of multimolecular chromatin-bound complexes have helped ...

Creating Value with Repurposed Drugs in Neurological and Psychiatric Disorders

Targeting nanomaterials: future drugs for cancer chemotherapy

Correspondence: Tianfeng Chen 601, Huangpu Road, Guangzhou 510632, China Tel +86 20 8522 5962 Fax +86 20 8522 1263 Email [email protected] Concerning the recent articles published in your journal on multifunctional nanosystem for cancer chemotherapy. It should be an admirable approach to kill cancer cells, with the least side effects on normal tissues and cells. During the past few decades,...

Identification of repurposed small molecule drugs for chordoma therapy

Chordoma is a rare, slow growing malignant tumor arising from remnants of the fetal notochord. Surgery is the first choice for chordoma treatment, followed by radiotherapy, although postoperative complications remain significant. Recurrence of the disease occurs frequently due to the anatomy of the tumor location and violation of the tumor margins at the initial surgery. Currently, there are no...